Where can I get naloxone in the state of North Carolina?

Naloxone is available under the statewide standing order through participating pharmacies. It is up to each individual pharmacy to decide whether to dispense naloxone under the statewide standing order or under a separate standing order. You can contact your local pharmacy to determine whether it is currently dispensing naloxone under a standing order.

As the North Carolina Division of Public Health learns of pharmacy locations that intend to dispense naloxone under the statewide standing order or another standing order, it will add these pharmacies to this website.

If you are not able to obtain naloxone through a standing order at a pharmacy, you have other options to obtain naloxone. You may seek a prescription for naloxone from a health care provider. You may also get naloxone at some local health departments or from the NC Harm Reduction Coalition.


Naloxone is a medication used to treat an opioid overdose. Naloxone works by reversing the effects of opioids by temporarily binding to the same brain receptors as opioids.
Opioids are medications that relieve pain. They reduce the intensity of pain signals reaching the brain and affect those brain areas controlling emotion, which diminishes the effects of a painful stimulus. Learn More.

Examples of Opioids:

  • Morphine(MS Contin®)
  • Codeine
  • Hydrocodone (Vicodin®, Norco®) Hydromorphone (Dilaudid®)
  • Oxycodone(Percocet®, OxyContin®)
  • Oxymorphone (Opana®)
  • Fentanyl (Duragesic®)
  • Buprenorphine(Subutex®)
  • Methadone
  • Heroin
 A standing order is a medical order that authorizes the dispensing of a medication, like naloxone, to any person who meets criteria designated by the prescriber.
  • Mixing opioids with certain other medicines, illegal drugs, or with alcohol
  • Taking opioids after a period of not being on them (recent release from prison/jail, discharge from an opioid “detox” program)
  • Taking an opioid called methadone
  • Taking high doses of opioids
  • Previous opioid overdose
  • Having kidney, liver, or breathing problems
  • Slow or shallow breathing
  • Blue or gray lips and fingernails
  • Pale and/or moist skin
  • Unable to wake up or respond

Step 1. Call 911.

Step 2. Follow the 911 dispatcher’s instructions or perform rescue breathing if comfortable doing so.

Step 3. Give naloxone.

Step 4. Give a second dose of naloxone in 2 to 5 minutes if there is no response to the first dose.

The key components of rescue breathing include the following:

Step 1. Make sure nothing is in the individual’s mouth.

Step 2. Tilt the head back, lift chin, and pinch nose shut.

Step 3. Give one slow breath every 5 seconds; chest should rise.

Yes. Naloxone reverses the effects of opioids, such as heroin, methadone, morphine, opium, codeine, or hydrocodone. It does not reverse the effects of drugs such as benzodiazepines (drugs including diazepam, midazolam, or alprazolam), antihistamines (like pheniramine or phenergan), alcohol, or other sedatives (drugs such as phenobarbital) or stimulants such as cocaine and amphetamines.
Naloxone can expire. It can also become less effective over time or after being exposed to too much cold, heat or sunlight. Expired naloxone is not harmful, but it has a reduced ability to reverse an overdose. To extend the lifetime of naloxone, it should be stored in a dark and dry place at room temperature.
The responses, which are anonymous and confidential, provide a better understanding of the way naloxone is being used in communities across NC and will help get more naloxone to the people who need it.